The aim of this case control study was to assess the effect of DHEA supplementation on pregnancy rates in a group of women with diminished ovarian function. There were 89 patients in the study group who received 75mg of oral, micronised DHEA daily for a period of up to 4 months prior to in vitro fertilisation. The control group consisted of 101 couples who received infertility treatment but no DHEA supplementation. Overall, the study found that there was a significantly higher cumulative pregnancy rate in the group receiving DHEA treatment, thus supporting the use of DHEA among women with diminished ovarian function.